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Unilateral corneal leukoplakia without limbal involvement
PURPOSE: Leukoplakia is the term given to a white patch or plaque that is found mainly on the oral mucus membrane. It can occasionally be seen on the corneal surface. We report our clinical and histopathological findings in a case of unilateral corneal leukoplakia. METHODS: A 26-year-old woman was r...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445867/ https://www.ncbi.nlm.nih.gov/pubmed/26056494 http://dx.doi.org/10.2147/IMCRJ.S82679 |
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author | Hirano, Koji Koide, Mihoko Mizoguchi, Yoshikazu Osakabe, Yasuhiro Sasaki, Kaoru-Araki |
author_facet | Hirano, Koji Koide, Mihoko Mizoguchi, Yoshikazu Osakabe, Yasuhiro Sasaki, Kaoru-Araki |
author_sort | Hirano, Koji |
collection | PubMed |
description | PURPOSE: Leukoplakia is the term given to a white patch or plaque that is found mainly on the oral mucus membrane. It can occasionally be seen on the corneal surface. We report our clinical and histopathological findings in a case of unilateral corneal leukoplakia. METHODS: A 26-year-old woman was referred to our hospital because of a white patch on her right cornea that continued to expand. She first noticed the white patch when she was 20 years old, and the white patch had expanded to cover the pupillary area affecting her vision. After plastic surgery on both eyelids for bilateral entropion to alleviate the pain caused by the eyelashes rubbing the cornea, the white corneal patch decreased in size. Because of this reduction, we performed surgery to remove the patch with microforceps under topical anesthesia. The plaque was removed easily and completely, and submitted for histopathological examination. RESULTS: Histopathological examination showed that the specimen had characteristics of epidermis with a basal cell layer, spinous cell layer, granular cell layer, and horny layer with hyperkeratosis. She was diagnosed with leukoplakia of the corneal surface. The basic structure of the squamous cell layer was preserved, and there were no signs of metaplasia. Six months after the removal of the leukoplakia, no recurrence was seen and her corrected decimal visual acuity recovered to 1.0. CONCLUSION: Our case of unilateral corneal leukoplakia without limbal involvement was most likely caused by chronic irritation of the cornea by the eyelashes. Although it was totally removed with good recovery of vision, we continue to follow the patient because of the potential of malignant transformation. |
format | Online Article Text |
id | pubmed-4445867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44458672015-06-08 Unilateral corneal leukoplakia without limbal involvement Hirano, Koji Koide, Mihoko Mizoguchi, Yoshikazu Osakabe, Yasuhiro Sasaki, Kaoru-Araki Int Med Case Rep J Case Report PURPOSE: Leukoplakia is the term given to a white patch or plaque that is found mainly on the oral mucus membrane. It can occasionally be seen on the corneal surface. We report our clinical and histopathological findings in a case of unilateral corneal leukoplakia. METHODS: A 26-year-old woman was referred to our hospital because of a white patch on her right cornea that continued to expand. She first noticed the white patch when she was 20 years old, and the white patch had expanded to cover the pupillary area affecting her vision. After plastic surgery on both eyelids for bilateral entropion to alleviate the pain caused by the eyelashes rubbing the cornea, the white corneal patch decreased in size. Because of this reduction, we performed surgery to remove the patch with microforceps under topical anesthesia. The plaque was removed easily and completely, and submitted for histopathological examination. RESULTS: Histopathological examination showed that the specimen had characteristics of epidermis with a basal cell layer, spinous cell layer, granular cell layer, and horny layer with hyperkeratosis. She was diagnosed with leukoplakia of the corneal surface. The basic structure of the squamous cell layer was preserved, and there were no signs of metaplasia. Six months after the removal of the leukoplakia, no recurrence was seen and her corrected decimal visual acuity recovered to 1.0. CONCLUSION: Our case of unilateral corneal leukoplakia without limbal involvement was most likely caused by chronic irritation of the cornea by the eyelashes. Although it was totally removed with good recovery of vision, we continue to follow the patient because of the potential of malignant transformation. Dove Medical Press 2015-05-18 /pmc/articles/PMC4445867/ /pubmed/26056494 http://dx.doi.org/10.2147/IMCRJ.S82679 Text en © 2015 Hirano et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Hirano, Koji Koide, Mihoko Mizoguchi, Yoshikazu Osakabe, Yasuhiro Sasaki, Kaoru-Araki Unilateral corneal leukoplakia without limbal involvement |
title | Unilateral corneal leukoplakia without limbal involvement |
title_full | Unilateral corneal leukoplakia without limbal involvement |
title_fullStr | Unilateral corneal leukoplakia without limbal involvement |
title_full_unstemmed | Unilateral corneal leukoplakia without limbal involvement |
title_short | Unilateral corneal leukoplakia without limbal involvement |
title_sort | unilateral corneal leukoplakia without limbal involvement |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445867/ https://www.ncbi.nlm.nih.gov/pubmed/26056494 http://dx.doi.org/10.2147/IMCRJ.S82679 |
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