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Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies

OBJECTIVE: To assess the relationship between race and spontaneous abortion, whether the relationship varies by risk factors, and the effect of spontaneous abortions on subsequent pregnancies. METHODS: A retrospective study was undertaken using data collected in London, UK, between 1988 and 2000. Lo...

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Autores principales: Oliver-Williams, Clare T., Steer, Philip J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445929/
https://www.ncbi.nlm.nih.gov/pubmed/25799528
http://dx.doi.org/10.1016/j.ijgo.2015.01.004
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author Oliver-Williams, Clare T.
Steer, Philip J.
author_facet Oliver-Williams, Clare T.
Steer, Philip J.
author_sort Oliver-Williams, Clare T.
collection PubMed
description OBJECTIVE: To assess the relationship between race and spontaneous abortion, whether the relationship varies by risk factors, and the effect of spontaneous abortions on subsequent pregnancies. METHODS: A retrospective study was undertaken using data collected in London, UK, between 1988 and 2000. Logistic regression evaluated histories of spontaneous abortion and associations with small-for-gestational-age and preterm births in black African, black Caribbean, and South Asian women relative to white European women. Interactions with risk factors were assessed. RESULTS: Overall, 196 040 women were included. Compared with white Europeans, the odds of a previous spontaneous abortion were increased in black African (adjusted odds ratio [aOR] 1.20; 95% confidence interval [CI] 1.12–1.29) and black Caribbean women (aOR 1.31; 95% CI 1.21–1.41). The strength of the association with black African race increased with age (P = 0.002), and the association with South Asian race increased with age and body mass index (P < 0.001 for both). Spontaneous abortion was associated with preterm birth in all races, but was strongest in black African women (aOR 1.47; 95% CI 1.29–1.67). CONCLUSION: The greater incidence of spontaneous abortion in black African and black Caribbean women should prompt further study of risk factors in relation to race. The interaction with age in black African and South Asian women could be important for counseling in relation to timing of pregnancy.
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spelling pubmed-44459292015-06-01 Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies Oliver-Williams, Clare T. Steer, Philip J. Int J Gynaecol Obstet Clinical Article OBJECTIVE: To assess the relationship between race and spontaneous abortion, whether the relationship varies by risk factors, and the effect of spontaneous abortions on subsequent pregnancies. METHODS: A retrospective study was undertaken using data collected in London, UK, between 1988 and 2000. Logistic regression evaluated histories of spontaneous abortion and associations with small-for-gestational-age and preterm births in black African, black Caribbean, and South Asian women relative to white European women. Interactions with risk factors were assessed. RESULTS: Overall, 196 040 women were included. Compared with white Europeans, the odds of a previous spontaneous abortion were increased in black African (adjusted odds ratio [aOR] 1.20; 95% confidence interval [CI] 1.12–1.29) and black Caribbean women (aOR 1.31; 95% CI 1.21–1.41). The strength of the association with black African race increased with age (P = 0.002), and the association with South Asian race increased with age and body mass index (P < 0.001 for both). Spontaneous abortion was associated with preterm birth in all races, but was strongest in black African women (aOR 1.47; 95% CI 1.29–1.67). CONCLUSION: The greater incidence of spontaneous abortion in black African and black Caribbean women should prompt further study of risk factors in relation to race. The interaction with age in black African and South Asian women could be important for counseling in relation to timing of pregnancy. Elsevier 2015-06 /pmc/articles/PMC4445929/ /pubmed/25799528 http://dx.doi.org/10.1016/j.ijgo.2015.01.004 Text en <?tlsb=-0.21pt?>© 2015 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Clinical Article
Oliver-Williams, Clare T.
Steer, Philip J.
Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
title Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
title_full Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
title_fullStr Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
title_full_unstemmed Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
title_short Racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
title_sort racial variation in the number of spontaneous abortions before a first successful pregnancy, and effects on subsequent pregnancies
topic Clinical Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4445929/
https://www.ncbi.nlm.nih.gov/pubmed/25799528
http://dx.doi.org/10.1016/j.ijgo.2015.01.004
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