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Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction

OBJECTIVE: Carbohydrate metabolism disorders (CMD) significantly impact the development and progression of all forms of ischemic heart disease, and inflammation is regarded as a general pathogenetic link between CMD and ischemic heart disease. METHODS: A total of 601 patients with ST segment elevati...

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Autores principales: Belenkova, Yulia, Karetnikova, Viktoria, Diachenko, Aleksey, Gruzdeva, Olga, Blagoveshchenskaya, Olga, Molodtsova, Tatiana, Uchasova, Evgenya, Barbarash, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446019/
https://www.ncbi.nlm.nih.gov/pubmed/26056485
http://dx.doi.org/10.2147/JIR.S76304
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author Belenkova, Yulia
Karetnikova, Viktoria
Diachenko, Aleksey
Gruzdeva, Olga
Blagoveshchenskaya, Olga
Molodtsova, Tatiana
Uchasova, Evgenya
Barbarash, Olga
author_facet Belenkova, Yulia
Karetnikova, Viktoria
Diachenko, Aleksey
Gruzdeva, Olga
Blagoveshchenskaya, Olga
Molodtsova, Tatiana
Uchasova, Evgenya
Barbarash, Olga
author_sort Belenkova, Yulia
collection PubMed
description OBJECTIVE: Carbohydrate metabolism disorders (CMD) significantly impact the development and progression of all forms of ischemic heart disease, and inflammation is regarded as a general pathogenetic link between CMD and ischemic heart disease. METHODS: A total of 601 patients with ST segment elevation myocardial infarction (MI) (STEMI), admitted within 24 hours from the onset of symptoms during 1 year, were included in this registry study. The blood levels of inflammation markers were measured at days 10–14 with further follow up at 1 year. RESULTS: The analysis of acute-phase percutaneous coronary intervention impact on the 1-year outcomes showed that endovascular revascularization significantly improved the 1-year prognosis of STEMI patients both with and without CMD. The analysis of inflammation markers showed significantly higher levels of interleukin (IL)-6 and sCD40L in MI patients with diabetes mellitus, and impaired glucose tolerance. Additionally, the patients with impaired glucose tolerance had significantly higher IL-12 levels. In the diabetic MI patients, the odds ratio of a poor 1-year outcome was high for patients with a high Killip classification of acute heart failure upon admission. CONCLUSION: Persistent inflammation in STEMI patients with CMD undergoing percutaneous coronary intervention might be responsible for vascular complications within 1 year after MI. Comorbid diabetes mellitus or impaired glucose tolerance can amplify the significance of the inflammatory response for the development of adverse 1-year outcomes.
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spelling pubmed-44460192015-06-08 Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction Belenkova, Yulia Karetnikova, Viktoria Diachenko, Aleksey Gruzdeva, Olga Blagoveshchenskaya, Olga Molodtsova, Tatiana Uchasova, Evgenya Barbarash, Olga J Inflamm Res Original Research OBJECTIVE: Carbohydrate metabolism disorders (CMD) significantly impact the development and progression of all forms of ischemic heart disease, and inflammation is regarded as a general pathogenetic link between CMD and ischemic heart disease. METHODS: A total of 601 patients with ST segment elevation myocardial infarction (MI) (STEMI), admitted within 24 hours from the onset of symptoms during 1 year, were included in this registry study. The blood levels of inflammation markers were measured at days 10–14 with further follow up at 1 year. RESULTS: The analysis of acute-phase percutaneous coronary intervention impact on the 1-year outcomes showed that endovascular revascularization significantly improved the 1-year prognosis of STEMI patients both with and without CMD. The analysis of inflammation markers showed significantly higher levels of interleukin (IL)-6 and sCD40L in MI patients with diabetes mellitus, and impaired glucose tolerance. Additionally, the patients with impaired glucose tolerance had significantly higher IL-12 levels. In the diabetic MI patients, the odds ratio of a poor 1-year outcome was high for patients with a high Killip classification of acute heart failure upon admission. CONCLUSION: Persistent inflammation in STEMI patients with CMD undergoing percutaneous coronary intervention might be responsible for vascular complications within 1 year after MI. Comorbid diabetes mellitus or impaired glucose tolerance can amplify the significance of the inflammatory response for the development of adverse 1-year outcomes. Dove Medical Press 2015-05-20 /pmc/articles/PMC4446019/ /pubmed/26056485 http://dx.doi.org/10.2147/JIR.S76304 Text en © 2015 Belenkova et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Belenkova, Yulia
Karetnikova, Viktoria
Diachenko, Aleksey
Gruzdeva, Olga
Blagoveshchenskaya, Olga
Molodtsova, Tatiana
Uchasova, Evgenya
Barbarash, Olga
Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction
title Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction
title_full Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction
title_fullStr Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction
title_full_unstemmed Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction
title_short Association of inflammatory markers and poor outcome in diabetic patients presenting with ST segment elevation myocardial infarction
title_sort association of inflammatory markers and poor outcome in diabetic patients presenting with st segment elevation myocardial infarction
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446019/
https://www.ncbi.nlm.nih.gov/pubmed/26056485
http://dx.doi.org/10.2147/JIR.S76304
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