Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

BACKGROUND: Rett syndrome (RTT) is one of the most prevalent neurodevelopmental disorders in females, caused by de novo mutations in the X-linked methyl CpG-binding protein 2 gene, MECP2. Although abnormal regulation of neuronal genes due to mutant MeCP2 is thought to induce autistic behavior and im...

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Detalles Bibliográficos
Autores principales: Andoh-Noda, Tomoko, Akamatsu, Wado, Miyake, Kunio, Matsumoto, Takuya, Yamaguchi, Ryo, Sanosaka, Tsukasa, Okada, Yohei, Kobayashi, Tetsuro, Ohyama, Manabu, Nakashima, Kinichi, Kurosawa, Hiroshi, Kubota, Takeo, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446051/
https://www.ncbi.nlm.nih.gov/pubmed/26012557
http://dx.doi.org/10.1186/s13041-015-0121-2

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