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Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry
OBJECTIVE: Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA and hepatic steatosis defined by computed tomography (CT). METHODS: We conduct...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446168/ https://www.ncbi.nlm.nih.gov/pubmed/25959049 http://dx.doi.org/10.1002/oby.21058 |
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author | Long, Michelle T. Pedley, Alison Massaro, Joseph M. Hoffmann, Udo Esliger, Dale W. Vasan, Ramachandran S. Fox, Caroline S. Murabito, Joanne M. |
author_facet | Long, Michelle T. Pedley, Alison Massaro, Joseph M. Hoffmann, Udo Esliger, Dale W. Vasan, Ramachandran S. Fox, Caroline S. Murabito, Joanne M. |
author_sort | Long, Michelle T. |
collection | PubMed |
description | OBJECTIVE: Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA and hepatic steatosis defined by computed tomography (CT). METHODS: We conducted a cross-sectional study of 1060 Framingham Heart Study participants who participated in the Multi-Detector CT 2 substudy and who underwent assessment of PA via accelerometry. Hepatic steatosis was estimated by liver attenuation, as measured by CT. We explored the relationship between liver attenuation and PA using multivariable regression models. RESULTS: In multivariable-adjusted models, we observed an inverse association between PA and liver attenuation. Each 30 min/day increase in moderate-to-vigorous PA (MVPA) was associated with a reduced odds of hepatic steatosis (OR=0.62, p<0.001). This association was attenuated and no longer statistically significant after adjustment for BMI (OR=0.77, p=0.05) or VAT (OR=0.83, p=0.18). Participants who met the national PA recommendations of engaging in ≥150 minutes/week of MVPA, had the lowest odds of hepatic steatosis, even after adjusting for BMI (OR=0.63, p=0.007) or VAT (OR=0.67, p=0.03). CONCLUSIONS: There is an inverse association between PA and hepatic steatosis. Participants who met the national PA guidelines had the lowest prevalence of hepatic steatosis. |
format | Online Article Text |
id | pubmed-4446168 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-44461682016-05-18 Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry Long, Michelle T. Pedley, Alison Massaro, Joseph M. Hoffmann, Udo Esliger, Dale W. Vasan, Ramachandran S. Fox, Caroline S. Murabito, Joanne M. Obesity (Silver Spring) Article OBJECTIVE: Prior studies on the association of physical activity (PA) and non-alcoholic fatty liver disease are limited by reliance on subjective measures of PA. We examined the association between objectively measured PA and hepatic steatosis defined by computed tomography (CT). METHODS: We conducted a cross-sectional study of 1060 Framingham Heart Study participants who participated in the Multi-Detector CT 2 substudy and who underwent assessment of PA via accelerometry. Hepatic steatosis was estimated by liver attenuation, as measured by CT. We explored the relationship between liver attenuation and PA using multivariable regression models. RESULTS: In multivariable-adjusted models, we observed an inverse association between PA and liver attenuation. Each 30 min/day increase in moderate-to-vigorous PA (MVPA) was associated with a reduced odds of hepatic steatosis (OR=0.62, p<0.001). This association was attenuated and no longer statistically significant after adjustment for BMI (OR=0.77, p=0.05) or VAT (OR=0.83, p=0.18). Participants who met the national PA recommendations of engaging in ≥150 minutes/week of MVPA, had the lowest odds of hepatic steatosis, even after adjusting for BMI (OR=0.63, p=0.007) or VAT (OR=0.67, p=0.03). CONCLUSIONS: There is an inverse association between PA and hepatic steatosis. Participants who met the national PA guidelines had the lowest prevalence of hepatic steatosis. 2015-05-09 2015-06 /pmc/articles/PMC4446168/ /pubmed/25959049 http://dx.doi.org/10.1002/oby.21058 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Long, Michelle T. Pedley, Alison Massaro, Joseph M. Hoffmann, Udo Esliger, Dale W. Vasan, Ramachandran S. Fox, Caroline S. Murabito, Joanne M. Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry |
title | Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry |
title_full | Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry |
title_fullStr | Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry |
title_full_unstemmed | Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry |
title_short | Hepatic Steatosis is Associated with Lower Levels of Physical Activity Measured via Accelerometry |
title_sort | hepatic steatosis is associated with lower levels of physical activity measured via accelerometry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446168/ https://www.ncbi.nlm.nih.gov/pubmed/25959049 http://dx.doi.org/10.1002/oby.21058 |
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