A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma

BACKGROUND: Neuroblastoma (NB) is the most common cancer in infancy and most frequent cause of death from extracranial solid tumors in children. Ornithine decarboxylase (ODC) expression is an independent indicator of poor prognosis in NB patients. This study investigated safety, response, pharmacoki...

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Detalles Bibliográficos
Autores principales: Saulnier Sholler, Giselle L., Gerner, Eugene W., Bergendahl, Genevieve, MacArthur, Robert B., VanderWerff, Alyssa, Ashikaga, Takamaru, Bond, Jeffrey P., Ferguson, William, Roberts, William, Wada, Randal K., Eslin, Don, Kraveka, Jacqueline M., Kaplan, Joel, Mitchell, Deanna, Parikh, Nehal S., Neville, Kathleen, Sender, Leonard, Higgins, Timothy, Kawakita, Masao, Hiramatsu, Kyoko, Moriya, Shun-suke, Bachmann, André S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446210/
https://www.ncbi.nlm.nih.gov/pubmed/26018967
http://dx.doi.org/10.1371/journal.pone.0127246

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