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FTO Inhibits Insulin Secretion and Promotes NF-κB Activation through Positively Regulating ROS Production in Pancreatic β cells

FTO (Fat mass and obesity-associated) is associated with increased risk of obesity and type 2 diabetes incurrence. Pancreas islet β cells dysfunction and insulin resistance are major causes of type 2 diabetes. However, whether FTO plays an important functional role in pancreatic β cells as well as t...

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Detalles Bibliográficos
Autores principales:	Fan, Hong-Qi, He, Wei, Xu, Kuan-Feng, Wang, Zhi-Xiao, Xu, Xin-Yu, Chen, Heng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446323/ https://www.ncbi.nlm.nih.gov/pubmed/26018652 http://dx.doi.org/10.1371/journal.pone.0127705

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