Cargando…
Structure-Activity Relationships for the Antifungal Activity of Selective Estrogen Receptor Antagonists Related to Tamoxifen
Cryptococcosis is one of the most important invasive fungal infections and is a significant contributor to the mortality associated with HIV/AIDS. As part of our program to repurpose molecules related to the selective estrogen receptor modulator (SERM) tamoxifen as anti-cryptococcal agents, we have...
Autores principales: | Butts, Arielle, Martin, Jennifer A., DiDone, Louis, Bradley, Erin K., Mutz, Mitchell, Krysan, Damian J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446328/ https://www.ncbi.nlm.nih.gov/pubmed/26016941 http://dx.doi.org/10.1371/journal.pone.0125927 |
Ejemplares similares
-
Antifungal Drug Discovery: Something Old and Something New
por: Butts, Arielle, et al.
Publicado: (2012) -
Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with Fluconazole In Vivo
por: Butts, Arielle, et al.
Publicado: (2014) -
Antitumor/Antifungal Celecoxib Derivative AR-12 is
a Non-Nucleoside Inhibitor of the ANL-Family Adenylating Enzyme Acetyl
CoA Synthetase
por: Koselny, Kristy, et al.
Publicado: (2016) -
Repurposing Estrogen Receptor Antagonists for the Treatment of Infectious Disease
por: Montoya, Marhiah C., et al.
Publicado: (2018) -
A High Throughput Screening Assay for Anti-Mycobacterial Small Molecules Based on Adenylate Kinase Release as a Reporter of Cell Lysis
por: Forbes, Lauren, et al.
Publicado: (2015)