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Identification of recurrent regulated alternative splicing events across human solid tumors
Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in mu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446417/ https://www.ncbi.nlm.nih.gov/pubmed/25908786 http://dx.doi.org/10.1093/nar/gkv210 |
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author | Danan-Gotthold, Miri Golan-Gerstl, Regina Eisenberg, Eli Meir, Keren Karni, Rotem Levanon, Erez Y. |
author_facet | Danan-Gotthold, Miri Golan-Gerstl, Regina Eisenberg, Eli Meir, Keren Karni, Rotem Levanon, Erez Y. |
author_sort | Danan-Gotthold, Miri |
collection | PubMed |
description | Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in multiple cancer types are enriched for such driver events. Here, we studied splicing alterations in hundreds of matched tumor and normal RNA-seq samples of eight solid cancer types. We found hundreds of cassette exons for which splicing was altered in multiple cancer types and identified a set of highly frequent altered splicing events. Specific splicing regulators, including RBFOX2, MBNL1/2 and QKI, appear to account for many splicing alteration events in multiple cancer types. Together, our results provide a first global analysis of regulated splicing alterations in cancer and identify common events with a potential causative role in solid tumor development. |
format | Online Article Text |
id | pubmed-4446417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-44464172015-06-15 Identification of recurrent regulated alternative splicing events across human solid tumors Danan-Gotthold, Miri Golan-Gerstl, Regina Eisenberg, Eli Meir, Keren Karni, Rotem Levanon, Erez Y. Nucleic Acids Res RNA Cancer is a complex disease that involves aberrant gene expression regulation. Discriminating the modified expression patterns driving tumor biology from the many that have no or little contribution is important for understanding cancer molecular basis. Recurrent deregulation patterns observed in multiple cancer types are enriched for such driver events. Here, we studied splicing alterations in hundreds of matched tumor and normal RNA-seq samples of eight solid cancer types. We found hundreds of cassette exons for which splicing was altered in multiple cancer types and identified a set of highly frequent altered splicing events. Specific splicing regulators, including RBFOX2, MBNL1/2 and QKI, appear to account for many splicing alteration events in multiple cancer types. Together, our results provide a first global analysis of regulated splicing alterations in cancer and identify common events with a potential causative role in solid tumor development. Oxford University Press 2015-05-26 2015-04-23 /pmc/articles/PMC4446417/ /pubmed/25908786 http://dx.doi.org/10.1093/nar/gkv210 Text en © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | RNA Danan-Gotthold, Miri Golan-Gerstl, Regina Eisenberg, Eli Meir, Keren Karni, Rotem Levanon, Erez Y. Identification of recurrent regulated alternative splicing events across human solid tumors |
title | Identification of recurrent regulated alternative splicing events across human solid tumors |
title_full | Identification of recurrent regulated alternative splicing events across human solid tumors |
title_fullStr | Identification of recurrent regulated alternative splicing events across human solid tumors |
title_full_unstemmed | Identification of recurrent regulated alternative splicing events across human solid tumors |
title_short | Identification of recurrent regulated alternative splicing events across human solid tumors |
title_sort | identification of recurrent regulated alternative splicing events across human solid tumors |
topic | RNA |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446417/ https://www.ncbi.nlm.nih.gov/pubmed/25908786 http://dx.doi.org/10.1093/nar/gkv210 |
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