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RPA70 depletion induces hSSB1/2-INTS3 complex to initiate ATR signaling

The primary eukaryotic single-stranded DNA-binding protein, Replication protein A (RPA), binds to single-stranded DNA at the sites of DNA damage and recruits the apical checkpoint kinase, ATR via its partner protein, ATRIP. It has been demonstrated that absence of RPA incapacitates the ATR-mediated...

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Detalles Bibliográficos
Autores principales:	Kar, Ananya, Kaur, Manpreet, Ghosh, Tanushree, Khan, Md. Muntaz, Sharma, Aparna, Shekhar, Ritu, Varshney, Akhil, Saxena, Sandeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446429/ https://www.ncbi.nlm.nih.gov/pubmed/25916848 http://dx.doi.org/10.1093/nar/gkv369

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