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RAR/RXR binding dynamics distinguish pluripotency from differentiation associated cis-regulatory elements

In mouse embryonic cells, ligand-activated retinoic acid receptors (RARs) play a key role in inhibiting pluripotency-maintaining genes and activating some major actors of cell differentiation. To investigate the mechanism underlying this dual regulation, we performed joint RAR/RXR ChIP-seq and mRNA-...

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Detalles Bibliográficos
Autores principales:	Chatagnon, Amandine, Veber, Philippe, Morin, Valérie, Bedo, Justin, Triqueneaux, Gérard, Sémon, Marie, Laudet, Vincent, d'Alché-Buc, Florence, Benoit, Gérard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446430/ https://www.ncbi.nlm.nih.gov/pubmed/25897113 http://dx.doi.org/10.1093/nar/gkv370

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