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High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation

Nucleoli are not only organelles that produce ribosomal subunits. They are also overarching sensors of different stress conditions and they control specific nucleolar stress pathways leading to stabilization of p53. During DNA replication, ATR and its activator TopBP1 initiate DNA damage response up...

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Detalles Bibliográficos
Autores principales:	Sokka, Miiko, Rilla, Kirsi, Miinalainen, Ilkka, Pospiech, Helmut, Syväoja, Juhani E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446431/ https://www.ncbi.nlm.nih.gov/pubmed/25916852 http://dx.doi.org/10.1093/nar/gkv371

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