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Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR–Cas9-mediated mutagenesis

Newly developed genome-editing tools, such as the clustered regularly interspaced short palindromic repeat (CRISPR)–Cas9 system, allow simple and rapid genetic modification in most model organisms and human cell lines. Here, we report the production and analysis of mice carrying the inactivation via...

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Detalles Bibliográficos
Autores principales:	Seruggia, Davide, Fernández, Almudena, Cantero, Marta, Pelczar, Pawel, Montoliu, Lluis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446435/ https://www.ncbi.nlm.nih.gov/pubmed/25897126 http://dx.doi.org/10.1093/nar/gkv375

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