The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA

Multiple myeloma, the second most frequent hematologic tumor after lymphomas, is an incurable cancer. Recent sequencing efforts have identified the ribonuclease DIS3 as one of the most frequently mutated genes in this disease. DIS3 represents the catalytic subunit of the exosome, a macromolecular co...

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Detalles Bibliográficos
Autores principales: Segalla, Simona, Pivetti, Silvia, Todoerti, Katia, Chudzik, Malgorzata Agata, Giuliani, Erica Claudia, Lazzaro, Federico, Volta, Viviana, Lazarevic, Dejan, Musco, Giovanna, Muzi-Falconi, Marco, Neri, Antonino, Biffo, Stefano, Tonon, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446438/
https://www.ncbi.nlm.nih.gov/pubmed/25925570
http://dx.doi.org/10.1093/nar/gkv387

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