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Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age

Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here, we investigated the associ...

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Autores principales: Akintola, Abimbola A., van den Berg, Annette, van Buchem, Mark A., Jansen, Steffy W., Slagboom, Eline P., Westendorp, Rudi G., van der Grond, Jeroen, van Heemst, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446544/
https://www.ncbi.nlm.nih.gov/pubmed/26074813
http://dx.doi.org/10.3389/fnagi.2015.00092
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author Akintola, Abimbola A.
van den Berg, Annette
van Buchem, Mark A.
Jansen, Steffy W.
Slagboom, Eline P.
Westendorp, Rudi G.
van der Grond, Jeroen
van Heemst, Diana
author_facet Akintola, Abimbola A.
van den Berg, Annette
van Buchem, Mark A.
Jansen, Steffy W.
Slagboom, Eline P.
Westendorp, Rudi G.
van der Grond, Jeroen
van Heemst, Diana
author_sort Akintola, Abimbola A.
collection PubMed
description Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here, we investigated the association between parameters of glucose metabolism and microstructural brain integrity in offspring of long-lived families (“offspring”) and controls; and age categories thereof. From the Leiden Longevity Study (LLS), 132 participants underwent an oral glucose tolerance test (OGTT) to assess glycemia [fasted glucose and glucose area-under-the-curve (AUC)], insulin resistance [fasted insulin, AUC(insulin), and homeostatic model assessment of insulin resistance (HOMA-IR)], and pancreatic Beta cell secretory capacity (insulinogenic index). 3 Tesla MRI and Magnetization Transfer (MT) imaging MT-ratio (MTR) peak-height was used to quantify differences in microstructural brain parenchymal tissue homogeneity that remain invisible on conventional MRI. Analyses were performed in offspring and age-matched controls, with and without stratification for age. In the full offspring group only, reduced MTR peak-height in gray and white matter was inversely associated with AUC(insulin), fasted insulin, HOMA-IR and insulinogenic-index (all p < 0.01). When dichotomized for age (≤65 years and >65 years): in younger controls, significantly stronger inverse associations were observed between MTR peak-height and fasted glucose, AUC(glucose), fasted insulin, AUC(insulin) and HOMA-IR in gray matter; and for AUC(glucose), fasted insulin and HOMA-IR in white matter (all P-interaction < 0.05). Although the strength of the associations tended to attenuate with age in the offspring group, the difference between age groups was not statistically significant. Thus, associations between impaired insulin action and reduced microstructural brain parenchymal tissue homogeneity were stronger in offspring compared to controls, and seemed to diminish with age.
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spelling pubmed-44465442015-06-12 Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age Akintola, Abimbola A. van den Berg, Annette van Buchem, Mark A. Jansen, Steffy W. Slagboom, Eline P. Westendorp, Rudi G. van der Grond, Jeroen van Heemst, Diana Front Aging Neurosci Neuroscience Impaired glucose metabolism and type 2 diabetes have been associated with cognitive decline, dementia, and with structural and functional brain features. However, it is unclear whether these associations differ in individuals that differ in familial longevity or age. Here, we investigated the association between parameters of glucose metabolism and microstructural brain integrity in offspring of long-lived families (“offspring”) and controls; and age categories thereof. From the Leiden Longevity Study (LLS), 132 participants underwent an oral glucose tolerance test (OGTT) to assess glycemia [fasted glucose and glucose area-under-the-curve (AUC)], insulin resistance [fasted insulin, AUC(insulin), and homeostatic model assessment of insulin resistance (HOMA-IR)], and pancreatic Beta cell secretory capacity (insulinogenic index). 3 Tesla MRI and Magnetization Transfer (MT) imaging MT-ratio (MTR) peak-height was used to quantify differences in microstructural brain parenchymal tissue homogeneity that remain invisible on conventional MRI. Analyses were performed in offspring and age-matched controls, with and without stratification for age. In the full offspring group only, reduced MTR peak-height in gray and white matter was inversely associated with AUC(insulin), fasted insulin, HOMA-IR and insulinogenic-index (all p < 0.01). When dichotomized for age (≤65 years and >65 years): in younger controls, significantly stronger inverse associations were observed between MTR peak-height and fasted glucose, AUC(glucose), fasted insulin, AUC(insulin) and HOMA-IR in gray matter; and for AUC(glucose), fasted insulin and HOMA-IR in white matter (all P-interaction < 0.05). Although the strength of the associations tended to attenuate with age in the offspring group, the difference between age groups was not statistically significant. Thus, associations between impaired insulin action and reduced microstructural brain parenchymal tissue homogeneity were stronger in offspring compared to controls, and seemed to diminish with age. Frontiers Media S.A. 2015-05-28 /pmc/articles/PMC4446544/ /pubmed/26074813 http://dx.doi.org/10.3389/fnagi.2015.00092 Text en Copyright © 2015 Akintola, van den Berg, van Buchem, Jansen, Slagboom, Westendorp, van der Grond and van Heemst. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Akintola, Abimbola A.
van den Berg, Annette
van Buchem, Mark A.
Jansen, Steffy W.
Slagboom, Eline P.
Westendorp, Rudi G.
van der Grond, Jeroen
van Heemst, Diana
Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
title Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
title_full Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
title_fullStr Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
title_full_unstemmed Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
title_short Associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
title_sort associations between insulin action and integrity of brain microstructure differ with familial longevity and with age
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446544/
https://www.ncbi.nlm.nih.gov/pubmed/26074813
http://dx.doi.org/10.3389/fnagi.2015.00092
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