Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the prolifer...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Tzu-Zin, Chen, Bo-Wei, Huang, Chiung-Yao, Hwang, Tsong-Long, Uvarani, Chokkalingam, Dai, Chang-Feng, Sung, Ping-Jyun, Su, Jui-Hsin, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446604/
https://www.ncbi.nlm.nih.gov/pubmed/25942094
http://dx.doi.org/10.3390/md13052757
Descripción
Sumario:Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.

Ejemplares similares