Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta

Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the prolifer...

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Autores principales: Huang, Tzu-Zin, Chen, Bo-Wei, Huang, Chiung-Yao, Hwang, Tsong-Long, Uvarani, Chokkalingam, Dai, Chang-Feng, Sung, Ping-Jyun, Su, Jui-Hsin, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446604/
https://www.ncbi.nlm.nih.gov/pubmed/25942094
http://dx.doi.org/10.3390/md13052757
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author Huang, Tzu-Zin
Chen, Bo-Wei
Huang, Chiung-Yao
Hwang, Tsong-Long
Uvarani, Chokkalingam
Dai, Chang-Feng
Sung, Ping-Jyun
Su, Jui-Hsin
Sheu, Jyh-Horng
author_facet Huang, Tzu-Zin
Chen, Bo-Wei
Huang, Chiung-Yao
Hwang, Tsong-Long
Uvarani, Chokkalingam
Dai, Chang-Feng
Sung, Ping-Jyun
Su, Jui-Hsin
Sheu, Jyh-Horng
author_sort Huang, Tzu-Zin
collection PubMed
description Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils.
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spelling pubmed-44466042015-05-29 Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta Huang, Tzu-Zin Chen, Bo-Wei Huang, Chiung-Yao Hwang, Tsong-Long Uvarani, Chokkalingam Dai, Chang-Feng Sung, Ping-Jyun Su, Jui-Hsin Sheu, Jyh-Horng Mar Drugs Article Four new eunicellin-type hirsutalins S–V (1–4), along with a known compound (–)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1–5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1–5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. MDPI 2015-04-30 /pmc/articles/PMC4446604/ /pubmed/25942094 http://dx.doi.org/10.3390/md13052757 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Huang, Tzu-Zin
Chen, Bo-Wei
Huang, Chiung-Yao
Hwang, Tsong-Long
Uvarani, Chokkalingam
Dai, Chang-Feng
Sung, Ping-Jyun
Su, Jui-Hsin
Sheu, Jyh-Horng
Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_full Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_fullStr Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_full_unstemmed Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_short Eunicellin-Based Diterpenoids, Hirsutalins S–V, from the Formosan Soft Coral Cladiella hirsuta
title_sort eunicellin-based diterpenoids, hirsutalins s–v, from the formosan soft coral cladiella hirsuta
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446604/
https://www.ncbi.nlm.nih.gov/pubmed/25942094
http://dx.doi.org/10.3390/md13052757
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