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Immunogenicity of infectious pathogens and vaccine antigens
The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenici...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446803/ https://www.ncbi.nlm.nih.gov/pubmed/26021448 http://dx.doi.org/10.1186/s12865-015-0095-y |
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author | Mahanty, Siddhartha Prigent, Antoine Garraud, Olivier |
author_facet | Mahanty, Siddhartha Prigent, Antoine Garraud, Olivier |
author_sort | Mahanty, Siddhartha |
collection | PubMed |
description | The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenicity as discussed in older textbooks of immunology needs reconsideration due to advances in our understanding of immunologic responses. Immunogenicity is a property that can either be a desirable attribute, for example in the generation of an effective protective immunity against infectious pathogens or an undesirable trait, for example when it relates to novel therapeutic compounds and drugs, where an immune response needs to be prevented or inhibited. In this Forum Article, we aimed to revisit the issue of immunogenicity to discuss a series of simple questions relevant to the concept that are frequently rephrased but incompletely resolved in the immunologic literature. |
format | Online Article Text |
id | pubmed-4446803 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-44468032015-05-29 Immunogenicity of infectious pathogens and vaccine antigens Mahanty, Siddhartha Prigent, Antoine Garraud, Olivier BMC Immunol Review The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenicity as discussed in older textbooks of immunology needs reconsideration due to advances in our understanding of immunologic responses. Immunogenicity is a property that can either be a desirable attribute, for example in the generation of an effective protective immunity against infectious pathogens or an undesirable trait, for example when it relates to novel therapeutic compounds and drugs, where an immune response needs to be prevented or inhibited. In this Forum Article, we aimed to revisit the issue of immunogenicity to discuss a series of simple questions relevant to the concept that are frequently rephrased but incompletely resolved in the immunologic literature. BioMed Central 2015-05-29 /pmc/articles/PMC4446803/ /pubmed/26021448 http://dx.doi.org/10.1186/s12865-015-0095-y Text en © Mahanty et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Mahanty, Siddhartha Prigent, Antoine Garraud, Olivier Immunogenicity of infectious pathogens and vaccine antigens |
title | Immunogenicity of infectious pathogens and vaccine antigens |
title_full | Immunogenicity of infectious pathogens and vaccine antigens |
title_fullStr | Immunogenicity of infectious pathogens and vaccine antigens |
title_full_unstemmed | Immunogenicity of infectious pathogens and vaccine antigens |
title_short | Immunogenicity of infectious pathogens and vaccine antigens |
title_sort | immunogenicity of infectious pathogens and vaccine antigens |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446803/ https://www.ncbi.nlm.nih.gov/pubmed/26021448 http://dx.doi.org/10.1186/s12865-015-0095-y |
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