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Immunogenicity of infectious pathogens and vaccine antigens

The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenici...

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Autores principales: Mahanty, Siddhartha, Prigent, Antoine, Garraud, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446803/
https://www.ncbi.nlm.nih.gov/pubmed/26021448
http://dx.doi.org/10.1186/s12865-015-0095-y
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author Mahanty, Siddhartha
Prigent, Antoine
Garraud, Olivier
author_facet Mahanty, Siddhartha
Prigent, Antoine
Garraud, Olivier
author_sort Mahanty, Siddhartha
collection PubMed
description The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenicity as discussed in older textbooks of immunology needs reconsideration due to advances in our understanding of immunologic responses. Immunogenicity is a property that can either be a desirable attribute, for example in the generation of an effective protective immunity against infectious pathogens or an undesirable trait, for example when it relates to novel therapeutic compounds and drugs, where an immune response needs to be prevented or inhibited. In this Forum Article, we aimed to revisit the issue of immunogenicity to discuss a series of simple questions relevant to the concept that are frequently rephrased but incompletely resolved in the immunologic literature.
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spelling pubmed-44468032015-05-29 Immunogenicity of infectious pathogens and vaccine antigens Mahanty, Siddhartha Prigent, Antoine Garraud, Olivier BMC Immunol Review The concept of the immunogenicity of an antigen is frequently encountered in the context of vaccine development, an area of intense interest currently due to the emergence or re-emergence of infectious pathogens with the potential for worldwide spread. However, the theoretical notion of immunogenicity as discussed in older textbooks of immunology needs reconsideration due to advances in our understanding of immunologic responses. Immunogenicity is a property that can either be a desirable attribute, for example in the generation of an effective protective immunity against infectious pathogens or an undesirable trait, for example when it relates to novel therapeutic compounds and drugs, where an immune response needs to be prevented or inhibited. In this Forum Article, we aimed to revisit the issue of immunogenicity to discuss a series of simple questions relevant to the concept that are frequently rephrased but incompletely resolved in the immunologic literature. BioMed Central 2015-05-29 /pmc/articles/PMC4446803/ /pubmed/26021448 http://dx.doi.org/10.1186/s12865-015-0095-y Text en © Mahanty et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Mahanty, Siddhartha
Prigent, Antoine
Garraud, Olivier
Immunogenicity of infectious pathogens and vaccine antigens
title Immunogenicity of infectious pathogens and vaccine antigens
title_full Immunogenicity of infectious pathogens and vaccine antigens
title_fullStr Immunogenicity of infectious pathogens and vaccine antigens
title_full_unstemmed Immunogenicity of infectious pathogens and vaccine antigens
title_short Immunogenicity of infectious pathogens and vaccine antigens
title_sort immunogenicity of infectious pathogens and vaccine antigens
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446803/
https://www.ncbi.nlm.nih.gov/pubmed/26021448
http://dx.doi.org/10.1186/s12865-015-0095-y
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