Microarray-based genomic profiling and in situ hybridization on fibrotic bone marrow biopsies for the identification of numerical chromosomal abnormalities in myelodysplastic syndrome

BACKGROUND: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematological malignancies. In MDS patients with a fibrotic bone marrow the aspiration of cells often fails (dry-tap), which hampers standard karyotyping. Obtaining genetic data from these fibrotic marrows is therefore c...

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Detalles Bibliográficos
Autores principales: Stevens-Kroef, Marian JPL, Hebeda, Konnie M, Verwiel, Eugène T, Kamping, Eveline J, van Cleef, Patricia H, Kuiper, Roland P, Groenen, Patricia JTA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447009/
https://www.ncbi.nlm.nih.gov/pubmed/26023320
http://dx.doi.org/10.1186/s13039-015-0136-5

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