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Insulin stimulates SGLT2-mediated tubular glucose absorption via oxidative stress generation

BACKGROUND: Ninety percent of glucose filtered by the glomerulus is reabsorbed by a sodium-glucose cotransporter 2 (SGLT2), which is expressed mainly on the apical membrane of renal proximal tubules. Since SGLT-2-mediated glucose reabsorption is enhanced under diabetic conditions, selective inhibiti...

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Detalles Bibliográficos
Autores principales:	Nakamura, Nobutaka, Matsui, Takanori, Ishibashi, Yuji, Yamagishi, Sho-ichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447012/ https://www.ncbi.nlm.nih.gov/pubmed/26023321 http://dx.doi.org/10.1186/s13098-015-0044-1

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