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Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy
A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals pre...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447085/ https://www.ncbi.nlm.nih.gov/pubmed/25640180 http://dx.doi.org/10.1016/j.celrep.2014.12.052 |
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author | Lynch, Vincent J. Nnamani, Mauris C. Kapusta, Aurélie Brayer, Kathryn Plaza, Silvia L. Mazur, Erik C. Emera, Deena Sheikh, Shehzad Z. Grützner, Frank Bauersachs, Stefan Graf, Alexander Young, Steven L. Lieb, Jason D. DeMayo, Francesco J. Feschotte, Cédric Wagner, Günter P. |
author_facet | Lynch, Vincent J. Nnamani, Mauris C. Kapusta, Aurélie Brayer, Kathryn Plaza, Silvia L. Mazur, Erik C. Emera, Deena Sheikh, Shehzad Z. Grützner, Frank Bauersachs, Stefan Graf, Alexander Young, Steven L. Lieb, Jason D. DeMayo, Francesco J. Feschotte, Cédric Wagner, Günter P. |
author_sort | Lynch, Vincent J. |
collection | PubMed |
description | A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the transition from egg laying to live birth. To determine the molecular bases of this transition, we characterized the pregnant/gravid uterine transcriptome from tetrapods to trace the evolutionary history of uterine gene expression. We show that thousands of genes evolved endometrial expression during the origins of mammalian pregnancy, including genes that mediate maternal-fetal communication and immunotolerance. Furthermore, thousands of cis-regulatory elements that mediate decidualization and cell-type identity in decidualized stromal cells are derived from ancient mammalian transposable elements (TEs). Our results indicate that one of the defining mammalian novelties evolved from DNA sequences derived from ancient mammalian TEs coopted into hormone-responsive regulatory elements distributed throughout the genome. |
format | Online Article Text |
id | pubmed-4447085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
record_format | MEDLINE/PubMed |
spelling | pubmed-44470852016-02-03 Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy Lynch, Vincent J. Nnamani, Mauris C. Kapusta, Aurélie Brayer, Kathryn Plaza, Silvia L. Mazur, Erik C. Emera, Deena Sheikh, Shehzad Z. Grützner, Frank Bauersachs, Stefan Graf, Alexander Young, Steven L. Lieb, Jason D. DeMayo, Francesco J. Feschotte, Cédric Wagner, Günter P. Cell Rep Article A major challenge in biology is determining how evolutionarily novel characters originate; however, mechanistic explanations for the origin of new characters are almost completely unknown. The evolution of pregnancy is an excellent system in which to study the origin of novelties because mammals preserve stages in the transition from egg laying to live birth. To determine the molecular bases of this transition, we characterized the pregnant/gravid uterine transcriptome from tetrapods to trace the evolutionary history of uterine gene expression. We show that thousands of genes evolved endometrial expression during the origins of mammalian pregnancy, including genes that mediate maternal-fetal communication and immunotolerance. Furthermore, thousands of cis-regulatory elements that mediate decidualization and cell-type identity in decidualized stromal cells are derived from ancient mammalian transposable elements (TEs). Our results indicate that one of the defining mammalian novelties evolved from DNA sequences derived from ancient mammalian TEs coopted into hormone-responsive regulatory elements distributed throughout the genome. 2015-01-29 2015-02-03 /pmc/articles/PMC4447085/ /pubmed/25640180 http://dx.doi.org/10.1016/j.celrep.2014.12.052 Text en ©2015 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/). |
spellingShingle | Article Lynch, Vincent J. Nnamani, Mauris C. Kapusta, Aurélie Brayer, Kathryn Plaza, Silvia L. Mazur, Erik C. Emera, Deena Sheikh, Shehzad Z. Grützner, Frank Bauersachs, Stefan Graf, Alexander Young, Steven L. Lieb, Jason D. DeMayo, Francesco J. Feschotte, Cédric Wagner, Günter P. Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy |
title | Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy |
title_full | Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy |
title_fullStr | Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy |
title_full_unstemmed | Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy |
title_short | Ancient Transposable Elements Transformed the Uterine Regulatory Landscape and Transcriptome during the Evolution of Mammalian Pregnancy |
title_sort | ancient transposable elements transformed the uterine regulatory landscape and transcriptome during the evolution of mammalian pregnancy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447085/ https://www.ncbi.nlm.nih.gov/pubmed/25640180 http://dx.doi.org/10.1016/j.celrep.2014.12.052 |
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