Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma

Inter-cellular communication with stromal cells is vital for cancer cells. Molecules involved in the communication are potential drug targets. To identify them systematically, we applied a systems level analysis that combined reverse network engineering with causal effect estimation. Using only obse...

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Detalles Bibliográficos
Autores principales: Engelmann, Julia C., Amann, Thomas, Ott-Rötzer, Birgitta, Nützel, Margit, Reinders, Yvonne, Reinders, Jörg, Thasler, Wolfgang E., Kristl, Theresa, Teufel, Andreas, Huber, Christian G., Oefner, Peter J., Spang, Rainer, Hellerbrand, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447342/
https://www.ncbi.nlm.nih.gov/pubmed/26020769
http://dx.doi.org/10.1371/journal.pcbi.1004293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447342/
https://www.ncbi.nlm.nih.gov/pubmed/26020769
http://dx.doi.org/10.1371/journal.pcbi.1004293

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