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Phospholipase D1 Couples CD4(+) T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication

Quiescent CD4+ T cells restrict human immunodeficiency virus type 1 (HIV-1) infection at early steps of virus replication. Low levels of both deoxyribonucleotide triphosphates (dNTPs) and the biosynthetic enzymes required for their de novo synthesis provide one barrier to infection. CD4+ T cell acti...

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Detalles Bibliográficos
Autores principales:	Taylor, Harry E., Simmons, Glenn E., Mathews, Thomas P., Khatua, Atanu K., Popik, Waldemar, Lindsley, Craig W., D’Aquila, Richard T., Brown, H. Alex
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447393/ https://www.ncbi.nlm.nih.gov/pubmed/26020637 http://dx.doi.org/10.1371/journal.ppat.1004864

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