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Mammalian Base Excision Repair: Functional Partnership between PARP-1 and APE1 in AP-Site Repair

The apurinic/apyrimidinic- (AP-) site in genomic DNA arises through spontaneous base loss and base removal by DNA glycosylases and is considered an abundant DNA lesion in mammalian cells. The base excision repair (BER) pathway repairs the AP-site lesion by excising and replacing the site with a norm...

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Detalles Bibliográficos
Autores principales:	Prasad, Rajendra, Dyrkheeva, Nadezhda, Williams, Jason, Wilson, Samuel H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447435/ https://www.ncbi.nlm.nih.gov/pubmed/26020771 http://dx.doi.org/10.1371/journal.pone.0124269

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