Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2

Huntington’s disease (HD) is a neurodegenerative illness, where selective neuronal loss in the brain caused by expression of mutant huntingtin protein leads to motor dysfunction and cognitive decline in addition to peripheral metabolic changes. In this study we confirm our previous observation of im...

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Autores principales: Nielsen, Signe Marie Borch, Hasholt, Lis, Nørremølle, Anne, Josefsen, Knud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447482/
https://www.ncbi.nlm.nih.gov/pubmed/26064782
http://dx.doi.org/10.1371/currents.hd.019b33aae1c519e6e8b68e7cf3e7818e
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author Nielsen, Signe Marie Borch
Hasholt, Lis
Nørremølle, Anne
Josefsen, Knud
author_facet Nielsen, Signe Marie Borch
Hasholt, Lis
Nørremølle, Anne
Josefsen, Knud
author_sort Nielsen, Signe Marie Borch
collection PubMed
description Huntington’s disease (HD) is a neurodegenerative illness, where selective neuronal loss in the brain caused by expression of mutant huntingtin protein leads to motor dysfunction and cognitive decline in addition to peripheral metabolic changes. In this study we confirm our previous observation of impairment of lactate-based hepatic gluconeogenesis in the transgenic HD mouse model R6/2 and determine that the defect manifests very early and progresses in severity with disease development, indicating a potential to explore this defect in a biomarker context. Moreover, R6/2 animals displayed lower blood glucose levels during prolonged fasting compared to wild type animals.
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spelling pubmed-44474822015-06-09 Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2 Nielsen, Signe Marie Borch Hasholt, Lis Nørremølle, Anne Josefsen, Knud PLoS Curr Research Huntington’s disease (HD) is a neurodegenerative illness, where selective neuronal loss in the brain caused by expression of mutant huntingtin protein leads to motor dysfunction and cognitive decline in addition to peripheral metabolic changes. In this study we confirm our previous observation of impairment of lactate-based hepatic gluconeogenesis in the transgenic HD mouse model R6/2 and determine that the defect manifests very early and progresses in severity with disease development, indicating a potential to explore this defect in a biomarker context. Moreover, R6/2 animals displayed lower blood glucose levels during prolonged fasting compared to wild type animals. Public Library of Science 2015-04-20 /pmc/articles/PMC4447482/ /pubmed/26064782 http://dx.doi.org/10.1371/currents.hd.019b33aae1c519e6e8b68e7cf3e7818e Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research
Nielsen, Signe Marie Borch
Hasholt, Lis
Nørremølle, Anne
Josefsen, Knud
Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2
title Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2
title_full Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2
title_fullStr Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2
title_full_unstemmed Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2
title_short Progressive Impairment of Lactate-based Gluconeogenesis in the Huntington’s Disease Mouse Model R6/2
title_sort progressive impairment of lactate-based gluconeogenesis in the huntington’s disease mouse model r6/2
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447482/
https://www.ncbi.nlm.nih.gov/pubmed/26064782
http://dx.doi.org/10.1371/currents.hd.019b33aae1c519e6e8b68e7cf3e7818e
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