Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response

Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of patients treated with Li achieve complete remission, and few markers of the response to tre...

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Autores principales: Geoffroy, Pierre Alexis, Etain, Bruno, Sportiche, Sarah, Bellivier, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447721/
https://www.ncbi.nlm.nih.gov/pubmed/26092399
http://dx.doi.org/10.1186/2194-7511-2-5
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author Geoffroy, Pierre Alexis
Etain, Bruno
Sportiche, Sarah
Bellivier, Frank
author_facet Geoffroy, Pierre Alexis
Etain, Bruno
Sportiche, Sarah
Bellivier, Frank
author_sort Geoffroy, Pierre Alexis
collection PubMed
description Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of patients treated with Li achieve complete remission, and few markers of the response to treatment have yet been identified for application in routine practice. Circadian biomarkers may be relevant predictors of individual responses to Li because (1) Li has been shown to affect circadian rhythms, (2) disrupted circadian rhythms are a core expression of susceptibility to BD, and (3) circadian abnormalities during euthymia are associated with relapses.
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spelling pubmed-44477212015-05-30 Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response Geoffroy, Pierre Alexis Etain, Bruno Sportiche, Sarah Bellivier, Frank Int J Bipolar Disord Letter to the Editor Bipolar disorder (BD) is a common, severe mental disorder with a high recurrence rate. Lithium (Li) is the cornerstone of BD treatments to reduce recurrence, suicide, and mortality risks. However, only 30% of patients treated with Li achieve complete remission, and few markers of the response to treatment have yet been identified for application in routine practice. Circadian biomarkers may be relevant predictors of individual responses to Li because (1) Li has been shown to affect circadian rhythms, (2) disrupted circadian rhythms are a core expression of susceptibility to BD, and (3) circadian abnormalities during euthymia are associated with relapses. Springer Berlin Heidelberg 2014-04-09 /pmc/articles/PMC4447721/ /pubmed/26092399 http://dx.doi.org/10.1186/2194-7511-2-5 Text en © Geoffroy et al.; licensee Springer. 2014 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Letter to the Editor
Geoffroy, Pierre Alexis
Etain, Bruno
Sportiche, Sarah
Bellivier, Frank
Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
title Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
title_full Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
title_fullStr Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
title_full_unstemmed Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
title_short Circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
title_sort circadian biomarkers in patients with bipolar disorder: promising putative predictors of lithium response
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447721/
https://www.ncbi.nlm.nih.gov/pubmed/26092399
http://dx.doi.org/10.1186/2194-7511-2-5
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