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Gene expression in the liver of female, but not male mice treated with rapamycin resembles changes observed under dietary restriction
It is well known that in mice the extension in lifespan by rapamycin is sexually dimorphic, in that it has a larger effect in females than males. In a previous study we showed that in male C57BL6 mice, rapamycin had less profound effects in both gene expression and liver metabolites when compared to...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447730/ https://www.ncbi.nlm.nih.gov/pubmed/26034704 http://dx.doi.org/10.1186/s40064-015-0909-7 |