LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2

SMYD2 is a lysine methyltransferase that catalyzes the monomethylation of several protein substrates including p53. SMYD2 is overexpressed in a significant percentage of esophageal squamous primary carcinomas, and that overexpression correlates with poor patient survival. However, the mechanism(s) b...

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Detalles Bibliográficos
Autores principales: Nguyen, Hannah, Allali-Hassani, Abdellah, Antonysamy, Stephen, Chang, Shawn, Chen, Lisa Hong, Curtis, Carmen, Emtage, Spencer, Fan, Li, Gheyi, Tarun, Li, Fengling, Liu, Shichong, Martin, Joseph R., Mendel, David, Olsen, Jonathan B., Pelletier, Laura, Shatseva, Tatiana, Wu, Song, Zhang, Feiyu Fred, Arrowsmith, Cheryl H., Brown, Peter J., Campbell, Robert M., Garcia, Benjamin A., Barsyte-Lovejoy, Dalia, Mader, Mary, Vedadi, Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Molecular Bases of Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447944/
https://www.ncbi.nlm.nih.gov/pubmed/25825497
http://dx.doi.org/10.1074/jbc.M114.626861

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