Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis

Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltrati...

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Autores principales: Muto, Yusuke, Fujimura, Taku, Kakizaki, Aya, Tsuchiyama, Kenichiro, Kusakari, Yoshiyuki, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Published online: April, 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448044/
https://www.ncbi.nlm.nih.gov/pubmed/26034476
http://dx.doi.org/10.1159/000381844
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author Muto, Yusuke
Fujimura, Taku
Kakizaki, Aya
Tsuchiyama, Kenichiro
Kusakari, Yoshiyuki
Aiba, Setsuya
author_facet Muto, Yusuke
Fujimura, Taku
Kakizaki, Aya
Tsuchiyama, Kenichiro
Kusakari, Yoshiyuki
Aiba, Setsuya
author_sort Muto, Yusuke
collection PubMed
description Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltration of IL-27-producing cells as well as MMP-7-and MMP-28-expressing cells, both of which have been reported to facilitate the development of autoimmune disease. Our present case might suggest possible mechanisms for acquired partial lipodystrophy.
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spelling pubmed-44480442015-06-01 Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis Muto, Yusuke Fujimura, Taku Kakizaki, Aya Tsuchiyama, Kenichiro Kusakari, Yoshiyuki Aiba, Setsuya Case Rep Dermatol Published online: April, 2015 Lipodystrophy is a group of metabolic disorders, possibly caused by autoimmune disease. In this report, we describe a case of adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis without a family history. Interestingly, immunohistochemical staining revealed dense infiltration of IL-27-producing cells as well as MMP-7-and MMP-28-expressing cells, both of which have been reported to facilitate the development of autoimmune disease. Our present case might suggest possible mechanisms for acquired partial lipodystrophy. S. Karger AG 2015-04-25 /pmc/articles/PMC4448044/ /pubmed/26034476 http://dx.doi.org/10.1159/000381844 Text en Copyright © 2015 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: April, 2015
Muto, Yusuke
Fujimura, Taku
Kakizaki, Aya
Tsuchiyama, Kenichiro
Kusakari, Yoshiyuki
Aiba, Setsuya
Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis
title Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis
title_full Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis
title_fullStr Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis
title_full_unstemmed Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis
title_short Adult-Onset Acquired Partial Lipodystrophy Accompanied by Rheumatoid Arthritis
title_sort adult-onset acquired partial lipodystrophy accompanied by rheumatoid arthritis
topic Published online: April, 2015
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448044/
https://www.ncbi.nlm.nih.gov/pubmed/26034476
http://dx.doi.org/10.1159/000381844
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