Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation

Regulatory T (Treg) cells play a pivotal role in suppressing self-harmful T cell responses, but how Treg cells mediate suppression to maintain immune homeostasis and limit responses during inflammation is unclear. Here we show that effector Treg cells express high amounts of the integrin αvβ8, which...

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Detalles Bibliográficos
Autores principales: Worthington, John J., Kelly, Aoife, Smedley, Catherine, Bauché, David, Campbell, Simon, Marie, Julien C., Travis, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448149/
https://www.ncbi.nlm.nih.gov/pubmed/25979421
http://dx.doi.org/10.1016/j.immuni.2015.04.012

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