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Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation

Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of cells, where it serves both as a building block for cell architecture and as a...

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Autores principales: Rivera, Io-Guané, Ordoñez, Marta, Presa, Natalia, Gomez-Larrauri, Ana, Simón, Jorge, Trueba, Miguel, Gomez-Muñoz, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448157/
https://www.ncbi.nlm.nih.gov/pubmed/25938271
http://dx.doi.org/10.3390/toxins7051457
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author Rivera, Io-Guané
Ordoñez, Marta
Presa, Natalia
Gomez-Larrauri, Ana
Simón, Jorge
Trueba, Miguel
Gomez-Muñoz, Antonio
author_facet Rivera, Io-Guané
Ordoñez, Marta
Presa, Natalia
Gomez-Larrauri, Ana
Simón, Jorge
Trueba, Miguel
Gomez-Muñoz, Antonio
author_sort Rivera, Io-Guané
collection PubMed
description Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of cells, where it serves both as a building block for cell architecture and as a precursor of bioactive sphingolipids. In particular, upregulation of (C-type) sphingomyelinases will produce ceramide, which regulates many physiological functions including apoptosis, senescence, or cell differentiation. Interestingly, the venom of some arthropodes including spiders of the genus Loxosceles, or the toxins of some bacteria such as Corynebacterium tuberculosis, or Vibrio damsela possess high levels of D-type sphingomyelinase (SMase D). This enzyme catalyzes the hydrolysis of SM to yield ceramide 1-phosphate (C1P), which promotes cell growth and survival and is a potent pro-inflammatory agent in different cell types. In particular, C1P stimulates cytosolic phospholipase A2 leading to arachidonic acid release and the subsequent formation of eicosanoids, actions that are all associated to the promotion of inflammation. In addition, C1P potently stimulates macrophage migration, which has also been associated to inflammatory responses. Interestingly, this action required the interaction of C1P with a specific plasma membrane receptor, whereas accumulation of intracellular C1P failed to stimulate chemotaxis. The C1P receptor is coupled to Gi proteins and activates of the PI3K/Akt and MEK/ERK1-2 pathways upon ligation with C1P. The proposed review will address novel aspects on the control of inflammatory responses by C1P and will highlight the molecular mechanisms whereby C1P exerts these actions.
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spelling pubmed-44481572015-06-01 Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation Rivera, Io-Guané Ordoñez, Marta Presa, Natalia Gomez-Larrauri, Ana Simón, Jorge Trueba, Miguel Gomez-Muñoz, Antonio Toxins (Basel) Review Sphingolipids are major constituents of biological membranes of eukaryotic cells. Many studies have shown that sphingomyelin (SM) is a major phospholipid in cell bilayers and is mainly localized to the plasma membrane of cells, where it serves both as a building block for cell architecture and as a precursor of bioactive sphingolipids. In particular, upregulation of (C-type) sphingomyelinases will produce ceramide, which regulates many physiological functions including apoptosis, senescence, or cell differentiation. Interestingly, the venom of some arthropodes including spiders of the genus Loxosceles, or the toxins of some bacteria such as Corynebacterium tuberculosis, or Vibrio damsela possess high levels of D-type sphingomyelinase (SMase D). This enzyme catalyzes the hydrolysis of SM to yield ceramide 1-phosphate (C1P), which promotes cell growth and survival and is a potent pro-inflammatory agent in different cell types. In particular, C1P stimulates cytosolic phospholipase A2 leading to arachidonic acid release and the subsequent formation of eicosanoids, actions that are all associated to the promotion of inflammation. In addition, C1P potently stimulates macrophage migration, which has also been associated to inflammatory responses. Interestingly, this action required the interaction of C1P with a specific plasma membrane receptor, whereas accumulation of intracellular C1P failed to stimulate chemotaxis. The C1P receptor is coupled to Gi proteins and activates of the PI3K/Akt and MEK/ERK1-2 pathways upon ligation with C1P. The proposed review will address novel aspects on the control of inflammatory responses by C1P and will highlight the molecular mechanisms whereby C1P exerts these actions. MDPI 2015-04-29 /pmc/articles/PMC4448157/ /pubmed/25938271 http://dx.doi.org/10.3390/toxins7051457 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rivera, Io-Guané
Ordoñez, Marta
Presa, Natalia
Gomez-Larrauri, Ana
Simón, Jorge
Trueba, Miguel
Gomez-Muñoz, Antonio
Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
title Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
title_full Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
title_fullStr Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
title_full_unstemmed Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
title_short Sphingomyelinase D/Ceramide 1-Phosphate in Cell Survival and Inflammation
title_sort sphingomyelinase d/ceramide 1-phosphate in cell survival and inflammation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448157/
https://www.ncbi.nlm.nih.gov/pubmed/25938271
http://dx.doi.org/10.3390/toxins7051457
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