Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid

During embryonic liver development, hepatic stem/progenitor cells (HpSCs) have a high proliferative ability and bipotency to differentiate into hepatocytes and cholangiocytes. Retinoic acid is a derivative of vitamin A and is involved in the proliferation and differentiation of stem/progenitor cells...

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Autor principal: Kamiya, Akihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448318/
https://www.ncbi.nlm.nih.gov/pubmed/26021438
http://dx.doi.org/10.1186/s13287-015-0099-9
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author Kamiya, Akihide
author_facet Kamiya, Akihide
author_sort Kamiya, Akihide
collection PubMed
description During embryonic liver development, hepatic stem/progenitor cells (HpSCs) have a high proliferative ability and bipotency to differentiate into hepatocytes and cholangiocytes. Retinoic acid is a derivative of vitamin A and is involved in the proliferation and differentiation of stem/progenitor cells in several tissues. However, whether retinoic acid regulates the characteristics of HpSCs in the normal liver is still unknown. A recent study has shown that acyclic retinoid regulates the survival and proliferation of HpSCs derived from mouse foetal liver. Acyclic retinoid suppressed the expansion of CD29(+)CD49f(+) HpSCs through the induction of hepatocytic differentiation and progression of apoptosis.
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spelling pubmed-44483182015-05-30 Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid Kamiya, Akihide Stem Cell Res Ther Commentary During embryonic liver development, hepatic stem/progenitor cells (HpSCs) have a high proliferative ability and bipotency to differentiate into hepatocytes and cholangiocytes. Retinoic acid is a derivative of vitamin A and is involved in the proliferation and differentiation of stem/progenitor cells in several tissues. However, whether retinoic acid regulates the characteristics of HpSCs in the normal liver is still unknown. A recent study has shown that acyclic retinoid regulates the survival and proliferation of HpSCs derived from mouse foetal liver. Acyclic retinoid suppressed the expansion of CD29(+)CD49f(+) HpSCs through the induction of hepatocytic differentiation and progression of apoptosis. BioMed Central 2015-05-29 /pmc/articles/PMC4448318/ /pubmed/26021438 http://dx.doi.org/10.1186/s13287-015-0099-9 Text en © Kamiya; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Kamiya, Akihide
Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
title Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
title_full Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
title_fullStr Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
title_full_unstemmed Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
title_short Regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
title_sort regulation of the survival and differentiation of hepatic stem/progenitor cells by acyclic retinoid
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448318/
https://www.ncbi.nlm.nih.gov/pubmed/26021438
http://dx.doi.org/10.1186/s13287-015-0099-9
work_keys_str_mv AT kamiyaakihide regulationofthesurvivalanddifferentiationofhepaticstemprogenitorcellsbyacyclicretinoid

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