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Decreased expression of CHIP leads to increased angiogenesis via VEGF-VEGFR2 pathway and poor prognosis in human renal cell carcinoma

CHIP (c-terminal Hsp70-interacting protein) is an E3 ligase which may play different roles in different cancers. The elucidation of the VHL-HIF-1α(hypoxia inducible factor-1α)-VEGF (vascular endothelial growth factor) pathway has led to the development of targeted therapy in renal cell carcinoma (RC...

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Detalles Bibliográficos
Autores principales:	Sun, Chao, Li, Hai-long, Chen, Hai-rong, Shi, Mei-lin, Liu, Qing-hua, Pan, Zhen-qiang, Bai, Jin, Zheng, Jun-nian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448523/ https://www.ncbi.nlm.nih.gov/pubmed/26021863 http://dx.doi.org/10.1038/srep09774

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