Synthesis of triarylmethanols via tandem arylation/oxidation of diarylmethanes

A tandem arylation/oxidation of diarylmethanes for the convenient synthesis of unsymmetrical triarylmethanols bearing different aryl and heteroaryl groups is described. A Pd(OAc)(2)–NiXantphos catalyst system efficiently catalyzed arylation of weakly acidic sp(3)-hybridized C–H bonds of diarylmethan...

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Detalles Bibliográficos
Autores principales: Mao, Jianyou, Eberle, Kelly, Zhang, Jiadi, Rodriguez, Carles, Xi, Zhenfeng, Pericàs, Miquel A., Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448728/
https://www.ncbi.nlm.nih.gov/pubmed/26034337
http://dx.doi.org/10.1016/j.tetlet.2015.01.189
Descripción
Sumario:A tandem arylation/oxidation of diarylmethanes for the convenient synthesis of unsymmetrical triarylmethanols bearing different aryl and heteroaryl groups is described. A Pd(OAc)(2)–NiXantphos catalyst system efficiently catalyzed arylation of weakly acidic sp(3)-hybridized C–H bonds of diarylmethanes with aryl bromides, and the arylation products were then oxidized in situ to carbinols by simply opening the reaction flasks to air. The triarylmethanol products were obtained in 35–98% yield.

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