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Potency of irritation by benzylidenemalononitriles in humans correlates with TRPA1 ion channel activation

We show that the physiological activity of solid aerosolized benzylidenemalononitriles (BMNs) including ‘tear gas’ (CS) in historic human volunteer trials correlates with activation of the human transient receptor potential ankyrin 1 ion channel (hTRPA1). This suggests that the irritation caused by...

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Detalles Bibliográficos
Autores principales:	Lindsay, Christopher D., Green, Christopher, Bird, Mike, Jones, James T. A., Riches, James R., McKee, Katherine K., Sandford, Mark S., Wakefield, Debra A., Timperley, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society Publishing 2015
Materias:	Biology (Whole Organism)
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448789/ https://www.ncbi.nlm.nih.gov/pubmed/26064575 http://dx.doi.org/10.1098/rsos.140160

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