Soluplus(®)/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan

BACKGROUND: Soluplus(®) (SP) and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)–based solid dispersion (SD) formulations were developed by hot-melt extrusion (HME) to improve oral bioavailability of valsartan (VST). METHODS: HME process with twin-screw configuration for generating a hi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Jae-Young, Kang, Wie-Soo, Piao, Jingpei, Yoon, In-Soo, Kim, Dae-Duk, Cho, Hyun-Jong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448925/
https://www.ncbi.nlm.nih.gov/pubmed/26045660
http://dx.doi.org/10.2147/DDDT.S84070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448925/
https://www.ncbi.nlm.nih.gov/pubmed/26045660
http://dx.doi.org/10.2147/DDDT.S84070

Ejemplares similares