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Soluplus(®)/TPGS-based solid dispersions prepared by hot-melt extrusion equipped with twin-screw systems for enhancing oral bioavailability of valsartan

BACKGROUND: Soluplus(®) (SP) and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)–based solid dispersion (SD) formulations were developed by hot-melt extrusion (HME) to improve oral bioavailability of valsartan (VST). METHODS: HME process with twin-screw configuration for generating a hi...

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Detalles Bibliográficos
Autores principales:	Lee, Jae-Young, Kang, Wie-Soo, Piao, Jingpei, Yoon, In-Soo, Kim, Dae-Duk, Cho, Hyun-Jong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448925/ https://www.ncbi.nlm.nih.gov/pubmed/26045660 http://dx.doi.org/10.2147/DDDT.S84070

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