Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma

Expanding knowledge about the crucial roles of microRNAs (miRNAs) in human diseases has led to the idea that miRNAs may be novel, promising therapeutic targets against various pathological conditions. The recent success of a human clinical trial using anti-miR-122 oligonucleotides against chronic he...

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Autores principales: Shibata, Chikako, Otsuka, Motoyuki, Kishikawa, Takahiro, Yoshikawa, Takeshi, Ohno, Motoko, Takata, Akemi, Koike, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448951/
https://www.ncbi.nlm.nih.gov/pubmed/26056570
http://dx.doi.org/10.1186/2052-8426-1-5
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author Shibata, Chikako
Otsuka, Motoyuki
Kishikawa, Takahiro
Yoshikawa, Takeshi
Ohno, Motoko
Takata, Akemi
Koike, Kazuhiko
author_facet Shibata, Chikako
Otsuka, Motoyuki
Kishikawa, Takahiro
Yoshikawa, Takeshi
Ohno, Motoko
Takata, Akemi
Koike, Kazuhiko
author_sort Shibata, Chikako
collection PubMed
description Expanding knowledge about the crucial roles of microRNAs (miRNAs) in human diseases has led to the idea that miRNAs may be novel, promising therapeutic targets against various pathological conditions. The recent success of a human clinical trial using anti-miR-122 oligonucleotides against chronic hepatitis C virus has paved the way for this approach. In this review, we summarize briefly the current status of clinical trials of miRNA-targeting therapy and several representative preclinical trials against hepato-gastrointestinal carcinoma. In addition, we describe the currently available technologies for modification and delivery of oligonucleotides, which are essential in providing efficient, specific and safe approaches to targeting miRNAs.
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spelling pubmed-44489512015-06-09 Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma Shibata, Chikako Otsuka, Motoyuki Kishikawa, Takahiro Yoshikawa, Takeshi Ohno, Motoko Takata, Akemi Koike, Kazuhiko Mol Cell Ther Review Expanding knowledge about the crucial roles of microRNAs (miRNAs) in human diseases has led to the idea that miRNAs may be novel, promising therapeutic targets against various pathological conditions. The recent success of a human clinical trial using anti-miR-122 oligonucleotides against chronic hepatitis C virus has paved the way for this approach. In this review, we summarize briefly the current status of clinical trials of miRNA-targeting therapy and several representative preclinical trials against hepato-gastrointestinal carcinoma. In addition, we describe the currently available technologies for modification and delivery of oligonucleotides, which are essential in providing efficient, specific and safe approaches to targeting miRNAs. BioMed Central 2013-12-13 /pmc/articles/PMC4448951/ /pubmed/26056570 http://dx.doi.org/10.1186/2052-8426-1-5 Text en © Shibata et al.; licensee BioMed Central Ltd. 2013 This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Shibata, Chikako
Otsuka, Motoyuki
Kishikawa, Takahiro
Yoshikawa, Takeshi
Ohno, Motoko
Takata, Akemi
Koike, Kazuhiko
Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma
title Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma
title_full Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma
title_fullStr Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma
title_full_unstemmed Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma
title_short Current status of miRNA-targeting therapeutics and preclinical studies against gastroenterological carcinoma
title_sort current status of mirna-targeting therapeutics and preclinical studies against gastroenterological carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448951/
https://www.ncbi.nlm.nih.gov/pubmed/26056570
http://dx.doi.org/10.1186/2052-8426-1-5
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