Cargando…

Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses

Dioscoreaceae, a kind of yam plant, has been recommended for treatment of chronic inflammatory conditions. However, the mechanisms are poorly defined. Methyl protodioscin (MPD) is one of the main bioactive components in Dioscoreaceae. Here, we aim to determine the mechanisms by which MPD ameliorates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Rongli, Gilbert, Shila, Yao, Xinsheng, Vallance, Jefferson, Steinbrecher, Kris, Moriggl, Richard, Zhang, Dongsheng, Eluri, Madhu, Chen, Haifeng, Cao, Huiqing, Shroyer, Noah, Denson, Lee, Han, Xiaonan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448980/ https://www.ncbi.nlm.nih.gov/pubmed/26038694 http://dx.doi.org/10.1002/prp2.118

Ejemplares similares

Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation
por: Gilbert, Shila, et al.
Publicado: (2012)

Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration
por: Gilbert, Shila, et al.
Publicado: (2015)

Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier
por: Han, Xiaonan, et al.
Publicado: (2011)

Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer
por: Chen, LianYu, et al.
Publicado: (2018)

Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine
por: Moore, Sean R., et al.
Publicado: (2014)

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia
por: Zhang, Dongsheng, et al.
Publicado: (2023)

Content of the Saponin Protodioscin in Brachiaria spp. from the Eastern Plains of Colombia
por: Lozano, Maria C., et al.
Publicado: (2017)

Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
por: Spence, Jason R., et al.
Publicado: (2010)

Transcriptome analysis of Asparagus officinalis reveals genes involved in the biosynthesis of rutin and protodioscin
por: Yi, Tae Gyu, et al.
Publicado: (2019)

A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation
por: Surbek, Marta, et al.
Publicado: (2021)

Protodioscin, Isolated from the Rhizome of Dioscorea tokoro Collected in Northern Japan is the Major Antiproliferative Compound to HL-60  Leukemic Cells
por: Oyama, Manami, et al.
Publicado: (2017)

Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens
por: Amarachintha, Surya, et al.
Publicado: (2018)

In vitro evaluation of dioscin and protodioscin against ER-positive and triple-negative breast cancer
por: Bouchmaa, Najat, et al.
Publicado: (2023)

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis
por: Liu, Ruixue, et al.
Publicado: (2019)

Methyl Protodioscin from the Roots of Asparagus cochinchinensis Attenuates Airway Inflammation by Inhibiting Cytokine Production
por: Lee, Ju Hee, et al.
Publicado: (2015)

The Steroid Saponin Protodioscin Modulates Arabidopsis thaliana Root Morphology Altering Auxin Homeostasis, Transport and Distribution
por: Santos Wagner, Ana Luiza, et al.
Publicado: (2021)

Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses
por: Finkbeiner, Stacy R., et al.
Publicado: (2012)

Mitophagy Effects of Protodioscin on Human Osteosarcoma Cells by Inhibition of p38MAPK Targeting NIX/LC3 Axis
por: Huang, Chien-Feng, et al.
Publicado: (2023)

Protodioscin protects porcine oocytes against H(2)O(2)-induced oxidative stress during in vitro maturation
por: Kim, So-Hee, et al.
Publicado: (2023)

Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in A549 human lung cancer cells
por: Bai, Yang, et al.
Publicado: (2014)

Lgr5(+) intestinal stem cell sorting and organoid culture
por: Liu, Ruixue, et al.
Publicado: (2019)

Transcriptional Regulation by ATOH1 and its Target SPDEF in the Intestine
por: Lo, Yuan-Hung, et al.
Publicado: (2016)

Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage
por: Ikpa, Pauline T., et al.
Publicado: (2016)

Inhibition of cathepsin S confers sensitivity to methyl protodioscin in oral cancer cells via activation of p38 MAPK/JNK signaling pathways
por: Hsieh, Ming-Ju, et al.
Publicado: (2017)

Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis
por: Peignon, Grégory, et al.
Publicado: (2011)

Activation of TGF‐β activated kinase 1 promotes colon mucosal pathogenesis in inflammatory bowel disease
por: Liu, Zhiwei, et al.
Publicado: (2017)

Misty mesentery, ascites, and bowel wall thickening in a child: Diagnostic clue for intestinal lymphangiectasia
por: Awal, Shila, et al.
Publicado: (2023)

Effects of compound small peptides of Chinese medicine on intestinal immunity and cecal intestinal flora in CTX immunosuppressed mice
por: Cui, Yuqing, et al.
Publicado: (2022)

Transcription factor Krüppel‐like factor 4 upregulated G protein‐coupled receptor 30 alleviates intestinal inflammation and apoptosis, and protects intestinal integrity from intestinal ischemia–reperfusion injury
por: Yin, Jie, et al.
Publicado: (2023)

Ontogeny and function of the circadian clock in intestinal organoids
por: Rosselot, Andrew E, et al.
Publicado: (2021)

Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids
por: Rajan, Anubama, et al.
Publicado: (2018)

Protodioscin Induces Mitochondrial Apoptosis of Human Hepatocellular Carcinoma Cells Through Eliciting ER Stress-Mediated IP3R Targeting Mfn1/Bak Expression
por: Yu, Chen-Lin, et al.
Publicado: (2022)

Antioxidant Indexes and Immune Function of the Intestinal Flora of Compound Microecological Preparations
por: Sun, Wanzhen, et al.
Publicado: (2022)

Cellular Plasticity of Defa4(Cre)-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury
por: Jones, Jennifer C., et al.
Publicado: (2018)

Genomic analysis of 1,25-dihydroxyvitamin D(3) action in mouse intestine reveals compartment and segment-specific gene regulatory effects
por: Aita, Rohit, et al.
Publicado: (2022)

The Role of Fruit by-Products as Bioactive Compounds for Intestinal Health
por: Chaouch, Mohamed Aymen, et al.
Publicado: (2020)

Pharmacokinetics and Intestinal Metabolism of Compound K in Rats and Mice
por: Jeon, Ji-Hyeon, et al.
Publicado: (2020)

Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds
por: Basson, Abigail Raffner, et al.
Publicado: (2021)

Impact of Food-Derived Bioactive Compounds on Intestinal Immunity
por: Zimmermann, Christian, et al.
Publicado: (2021)

Effect of a Traditional Chinese Medicine Formula (CoTOL) on Serum Uric Acid and Intestinal Flora in Obese Hyperuricemic Mice Inoculated with Intestinal Bacteria
por: Gao, Yan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_6u5vrg5lt5e4prqrdv1l70iqk5