Cargando…

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase

The metabolism of eldecalcitol (ED-71), a 2β-hydroxypropoxylated analog of the active form of vitamin D(3) was investigated by using in vitro systems. ED-71 was metabolized to 1α,2β,25-trihydroxyvitamin D(3) (1α,2β,25(OH)(3)D(3)) in human small intestine and liver microsomes. To identify the enzymes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yasuda, Kaori, Iwanaga, Yuasa, Ogawa, Kazuaki, Mano, Hiroki, Ueno, Sera, Kimoto, Shutaro, Ohta, Miho, Kamakura, Masaki, Ikushiro, Shinichi, Sakaki, Toshiyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448988/ https://www.ncbi.nlm.nih.gov/pubmed/26038696 http://dx.doi.org/10.1002/prp2.120

Ejemplares similares

Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis
por: Yasuda, Kaori, et al.
Publicado: (2015)

Eldecalcitol for the treatment of osteoporosis
por: Noguchi, Yuko, et al.
Publicado: (2013)

Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery
por: Yasuda, Kaori, et al.
Publicado: (2021)

Robust osteogenic efficacy of 2α-heteroarylalkyl vitamin D analogue AH-1 in VDR (R270L) hereditary vitamin D-dependent rickets model rats
por: Nishikawa, Miyu, et al.
Publicado: (2022)

Effects of eldecalcitol and ibandronate on secondary osteoporosis and muscle wasting in rats with adjuvant-induced arthritis
por: Ono, Yuichi, et al.
Publicado: (2018)

Overview of the clinical efficacy and safety of eldecalcitol for the treatment of osteoporosis
por: Cui, Lijia, et al.
Publicado: (2022)

Characterization of Rickets Type II Model Rats to Reveal Functions of Vitamin D and Vitamin D Receptor
por: Iwai, Yuichiro, et al.
Publicado: (2023)

Safety and Efficacy of Zoledronic Acid Treatment with and without Acetaminophen and Eldecalcitol for Osteoporosis
por: Mochizuki, Takeshi, et al.
Publicado: (2021)

Eldecalcitol reduces the risk of severe vertebral fractures and improves the health-related quality of life in patients with osteoporosis
por: Hagino, Hiroshi, et al.
Publicado: (2012)

Additive effects of eldecalcitol in poorly responding long-term bisphosphonate treatment for osteoporosis
por: Kamimura, Mikio, et al.
Publicado: (2019)

Efficacy and Safety of Eldecalcitol for Osteoporosis: A Meta-Analysis of Randomized Controlled Trials
por: Liu, Hongyan, et al.
Publicado: (2022)

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice
por: Hirota, Yoshihisa, et al.
Publicado: (2018)

Eldecalcitol, an active vitamin D analog, effectively prevents cyclophosphamide-induced osteoporosis in rats
por: Wang, Wei, et al.
Publicado: (2019)

Gene therapy for alopecia in type II rickets model rats using vitamin D receptor-expressing adenovirus vector
por: Kise, Satoko, et al.
Publicado: (2023)

Eldecalcitol is more effective for the prevention of osteoporotic fractures than alfacalcidol
por: Nakamura, Toshitaka, et al.
Publicado: (2013)

Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system
por: Yasuda, Kaori, et al.
Publicado: (2021)

The therapeutic effect to eldecalcitol + bisphosphonate is superior to bisphosphonate alone in the treatment of osteoporosis: a meta-analysis
por: Zheng, Zaoqian, et al.
Publicado: (2020)

Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions
por: Nishikawa, Miyu, et al.
Publicado: (2020)

Comparison of the Effects of Native Vitamin D and Eldecalcitol on Muscular Strength and Dynamic Balance in Patients with Postmenopausal Osteoporosis
por: Miyakoshi, Naohisa, et al.
Publicado: (2020)

Correction to: The therapeutic effect to eldecalcitol + bisphosphonate is superior to bisphosphonate alone in the treatment of osteoporosis: a meta-analysis
por: Zheng, Zaoqian, et al.
Publicado: (2020)

The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis
por: Shi, Tuo, et al.
Publicado: (2023)

Effects of monthly minodronate with or without eldecalcitol addition in osteoporosis patients with rheumatoid arthritis: An 18-month prospective study
por: Suzuki, Takako, et al.
Publicado: (2019)

Two-year effectiveness of zoledronic acid with or without eldecalcitol in Japanese patients with osteoporosis: A randomized prospective study
por: Mochizuki, Takeshi, et al.
Publicado: (2022)

Eldecalcitol prevented OVX-induced osteoporosis through inhibiting BMSCs senescence by regulating the SIRT1-Nrf2 signal
por: Kou, Yuying, et al.
Publicado: (2023)

Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D(3) Analogues and Their Stability to hCYP24A1-Dependent Catabolism
por: Kawagoe, Fumihiro, et al.
Publicado: (2021)

The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D(3) and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities
por: Mototani, Sayuri, et al.
Publicado: (2022)

Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials
por: Xu, Zhixing, et al.
Publicado: (2016)

Comparison of effectiveness and safety of ibandronate and minodronate combined with eldecalcitol in primary osteoporosis of women: A 1-year follow-up study
por: Tanaka, Mizue, et al.
Publicado: (2017)

Hypercalcemia and acute kidney injury induced by eldecalcitol in patients with osteoporosis: a case series of 32 patients at a single facility
por: Aihara, Seishi, et al.
Publicado: (2019)

Effects of eldecalcitol on cortical bone response to mechanical loading in rats
por: Yamasaki, Yusuke, et al.
Publicado: (2015)

Inhibition of vitamin D analog eldecalcitol on hepatoma in vitro and in vivo
por: Ye, Limin, et al.
Publicado: (2020)

Treatment of osteoporosis with eldecalcitol, a new vitamin D analog: a comprehensive review and meta-analysis of randomized clinical trials [Corrigendum]
Publicado: (2016)

Mammalian Cytochrome P450-Dependent Metabolism of Polychlorinated Dibenzo-p-dioxins and Coplanar Polychlorinated Biphenyls
por: Inui, Hideyuki, et al.
Publicado: (2014)

Pharmacokinetic and Bioequivalence Study of Eldecalcitol Soft Capsules in Healthy Chinese Subjects
por: Li, Ting, et al.
Publicado: (2022)

Eldecalcitol improves chair-rising time in postmenopausal osteoporotic women treated with bisphosphonates
por: Iwamoto, Jun, et al.
Publicado: (2014)

Eldecalcitol effects on osteoblastic differentiation and function in the presence or absence of osteoclastic bone resorption
por: Bu, Jie, et al.
Publicado: (2019)

Microbial production of novel sulphated alkaloids for drug discovery
por: Matsumura, Eitaro, et al.
Publicado: (2018)

In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme
por: Żołek, Teresa, et al.
Publicado: (2022)

Inhibiting C-4 Methyl Sterol Oxidase with Novel Diazaborines to Target Fungal Plant Pathogens
por: Kim, Sang Hu, et al.
Publicado: (2022)

Avian Cytochrome P450 (CYP) 1-3 Family Genes: Isoforms, Evolutionary Relationships, and mRNA Expression in Chicken Liver
por: Watanabe, Kensuke P., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1949ukal8jr18h6a4k86fkfvep