A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosa

Linaclotide, a synthetic guanylyl cyclase C (GC-C) agonist, and the prostone analog, Lubiprostone, are approved to manage chronic idiopathic constipation and constipation-predominant irritable bowel syndrome. Lubiprostone also protects intestinal mucosal barrier function in ischemia. GC-C signaling...

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Detalles Bibliográficos
Autores principales: Kang, Sang Bum, Marchelletta, Ronald R, Penrose, Harrison, Docherty, Michael J, McCole, Declan F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448989/
https://www.ncbi.nlm.nih.gov/pubmed/26038704
http://dx.doi.org/10.1002/prp2.128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448989/
https://www.ncbi.nlm.nih.gov/pubmed/26038704
http://dx.doi.org/10.1002/prp2.128

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