Bilateral single-site intracerebral injection of a nonpathogenic herpes simplex virus-1 vector decreases anxiogenic behavior in MPS VII mice

Genetic diseases of the brain usually have pathologic lesions distributed throughout, thus requiring global correction. Herpes simplex virus-1 (HSV-1) vectors may be especially useful for gene delivery in these disorders since they can spread trans-synaptically along neuronal pathways to distal site...

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Detalles Bibliográficos
Autores principales: Liu, Wenpei, Griffin, Gerald, Clarke, Trena, Parente, Michael K, Valentino, Rita J, Wolfe, John H, Fraser, Nigel W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448997/
https://www.ncbi.nlm.nih.gov/pubmed/26052529
http://dx.doi.org/10.1038/mtm.2014.59

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