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Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients
BACKGROUND: In Romania (latitude 48°15’N to 43°40’N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information is available regarding epidemiological data on vitamin D status in the Romanian population for a wide age range and geographical territory. In t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449004/ https://www.ncbi.nlm.nih.gov/pubmed/26024516 http://dx.doi.org/10.1371/journal.pone.0128010 |
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author | Chirita-Emandi, Adela Socolov, Demetra Haivas, Carmen Calapiș, Anca Gheorghiu, Cristina Puiu, Maria |
author_facet | Chirita-Emandi, Adela Socolov, Demetra Haivas, Carmen Calapiș, Anca Gheorghiu, Cristina Puiu, Maria |
author_sort | Chirita-Emandi, Adela |
collection | PubMed |
description | BACKGROUND: In Romania (latitude 48°15’N to 43°40’N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information is available regarding epidemiological data on vitamin D status in the Romanian population for a wide age range and geographical territory. In this context, we aimed to evaluate the seasonal and age variation of vitamin D status in a large Romanian population. METHODS: 6631 individuals from across Romania had performed 7544 vitamin D assessments (2012-2014) in a chain of private laboratories. Vitamin D (25-hydroxyvitamin D2 and 25-hydroxyvitamin D3) was measured using High Performance Liquid Chromatography. Vitamin D levels were classified as severe deficiency<10ng/mL, deficiency 10-20ng/mL, insufficiency 21-29ng/mL, sufficiency≥30ng/mL and potentially harmful>100ng/ml. RESULTS: Male to female ratio was 1:2.9. Age ranged from 0 to 85 years. Mean vitamin D levels increased from April (26.3ng/ml) to September (35.6ng/ml) and decreased from October (33.5ng/ml) to March (24.4 ng/ml). Overall 40% had sufficient vitamin D, while the rest were insufficient 33%, deficient 22%, severely deficient 4% and 1% potentially harmful (of them 81% under 1 year old). Males compared to females showed higher percentages of sufficiency (47% vs. 38%). Children 0- 2 years presented the highest percentage of vitamin D sufficiency (77%). Lowest percentages (21%) of sufficiency were in people 80-84 years. CONCLUSION: In Romania, suboptimal vitamin D levels are common (59%), especially in older age, wintertime and in women. Vitamin D supplementation would be most warranted from January to April in the Romanian population. 25-hydroxyvitamin D levels>100ng/ml were relatively prevalent in children 0-1 year old (17.3%). This was attributed to supplementation errors and the fact that high-risk individuals were more likely to visit for medical check-up. Nonetheless, it stresses the need to increase awareness of the importance of preventing Vitamin D supplementation administration errors in the young. |
format | Online Article Text |
id | pubmed-4449004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-44490042015-06-09 Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients Chirita-Emandi, Adela Socolov, Demetra Haivas, Carmen Calapiș, Anca Gheorghiu, Cristina Puiu, Maria PLoS One Research Article BACKGROUND: In Romania (latitude 48°15’N to 43°40’N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information is available regarding epidemiological data on vitamin D status in the Romanian population for a wide age range and geographical territory. In this context, we aimed to evaluate the seasonal and age variation of vitamin D status in a large Romanian population. METHODS: 6631 individuals from across Romania had performed 7544 vitamin D assessments (2012-2014) in a chain of private laboratories. Vitamin D (25-hydroxyvitamin D2 and 25-hydroxyvitamin D3) was measured using High Performance Liquid Chromatography. Vitamin D levels were classified as severe deficiency<10ng/mL, deficiency 10-20ng/mL, insufficiency 21-29ng/mL, sufficiency≥30ng/mL and potentially harmful>100ng/ml. RESULTS: Male to female ratio was 1:2.9. Age ranged from 0 to 85 years. Mean vitamin D levels increased from April (26.3ng/ml) to September (35.6ng/ml) and decreased from October (33.5ng/ml) to March (24.4 ng/ml). Overall 40% had sufficient vitamin D, while the rest were insufficient 33%, deficient 22%, severely deficient 4% and 1% potentially harmful (of them 81% under 1 year old). Males compared to females showed higher percentages of sufficiency (47% vs. 38%). Children 0- 2 years presented the highest percentage of vitamin D sufficiency (77%). Lowest percentages (21%) of sufficiency were in people 80-84 years. CONCLUSION: In Romania, suboptimal vitamin D levels are common (59%), especially in older age, wintertime and in women. Vitamin D supplementation would be most warranted from January to April in the Romanian population. 25-hydroxyvitamin D levels>100ng/ml were relatively prevalent in children 0-1 year old (17.3%). This was attributed to supplementation errors and the fact that high-risk individuals were more likely to visit for medical check-up. Nonetheless, it stresses the need to increase awareness of the importance of preventing Vitamin D supplementation administration errors in the young. Public Library of Science 2015-05-29 /pmc/articles/PMC4449004/ /pubmed/26024516 http://dx.doi.org/10.1371/journal.pone.0128010 Text en © 2015 Chirita-Emandi et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chirita-Emandi, Adela Socolov, Demetra Haivas, Carmen Calapiș, Anca Gheorghiu, Cristina Puiu, Maria Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients |
title | Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients |
title_full | Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients |
title_fullStr | Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients |
title_full_unstemmed | Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients |
title_short | Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients |
title_sort | vitamin d status: a different story in the very young versus the very old romanian patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449004/ https://www.ncbi.nlm.nih.gov/pubmed/26024516 http://dx.doi.org/10.1371/journal.pone.0128010 |
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