Increasing the minicircle DNA purity using an enhanced triplex DNA technology to eliminate DNA contaminants

DNA vectors for human gene therapy have to meet the efficacy and safety requirements. Minicircles (MCs), a class of optimized DNA vectors free of plasmid backbone (PB) DNAs, have emerged as promising candidates because of their superior transgene expression profiles. However, the existence of impure...

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Detalles Bibliográficos
Autores principales: Hou, Xiaohu H, Guo, Xiaoyan Y, Chen, Yusheng, He, Cheng-Yi, Chen, Zhi-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449018/
https://www.ncbi.nlm.nih.gov/pubmed/26052527
http://dx.doi.org/10.1038/mtm.2014.62

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449018/
https://www.ncbi.nlm.nih.gov/pubmed/26052527
http://dx.doi.org/10.1038/mtm.2014.62

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