Cargando…
Increasing the minicircle DNA purity using an enhanced triplex DNA technology to eliminate DNA contaminants
DNA vectors for human gene therapy have to meet the efficacy and safety requirements. Minicircles (MCs), a class of optimized DNA vectors free of plasmid backbone (PB) DNAs, have emerged as promising candidates because of their superior transgene expression profiles. However, the existence of impure...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449018/ https://www.ncbi.nlm.nih.gov/pubmed/26052527 http://dx.doi.org/10.1038/mtm.2014.62 |