The Unique Non-Catalytic C-Terminus of P37delta-PI3K Adds Proliferative Properties In Vitro and In Vivo

The PI3K/Akt pathway is central for numerous cellular functions and is frequently deregulated in human cancers. The catalytic subunits of PI3K, p110, are thought to have a potential oncogenic function, and the regulatory subunit p85 exerts tumor suppressor properties. The fruit fly, Drosophila melan...

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Detalles Bibliográficos
Autores principales: Ejeskär, Katarina, Vickes, Oscar, Kuchipudi, Arunakar, Wettergren, Yvonne, Uv, Anne, Rotter Sopasakis, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449119/
https://www.ncbi.nlm.nih.gov/pubmed/26024481
http://dx.doi.org/10.1371/journal.pone.0127497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449119/
https://www.ncbi.nlm.nih.gov/pubmed/26024481
http://dx.doi.org/10.1371/journal.pone.0127497

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