Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores

Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human bronchial epithelial cell cultures (HBECCs), maximal agonist-stimulated secretion exceeds baseline by ~3-fold as measured over hour-long per...

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Detalles Bibliográficos
Autores principales: Zhu, Yunxiang, Abdullah, Lubna H., Doyle, Sean P., Nguyen, Kristine, Ribeiro, Carla M. P., Vasquez, Paula A., Forest, M. Gregory, Lethem, Michael I., Dickey, Burton F., Davis, C. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449158/
https://www.ncbi.nlm.nih.gov/pubmed/26024524
http://dx.doi.org/10.1371/journal.pone.0127267

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