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Genetic Mechanism of Human Neutrophil Antigen 2 Deficiency and Expression Variations

Human neutrophil antigen 2 (HNA-2) deficiency is a common phenotype as 3–5% humans do not express HNA-2. HNA-2 is coded by CD177 gene that associates with human myeloproliferative disorders. HNA-2 deficient individuals are prone to produce HNA-2 alloantibodies that cause a number of disorders includ...

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Detalles Bibliográficos
Autores principales: Li, Yunfang, Mair, David C., Schuller, Randy M., Li, Ling, Wu, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449163/
https://www.ncbi.nlm.nih.gov/pubmed/26024230
http://dx.doi.org/10.1371/journal.pgen.1005255