Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma

β(2)-adrenergic receptor (β(2)AR) agonists (β(2)-agonist) are the most commonly used therapy for acute relief in asthma, but chronic use of these bronchodilators paradoxically exacerbates airway hyper-responsiveness. Activation of βARs by β-agonist leads to desensitization (inactivation) by phosphor...

Descripción completa

Detalles Bibliográficos
Autores principales: Gupta, Manveen K., Asosingh, Kewal, Aronica, Mark, Comhair, Suzy, Cao, Gaoyuan, Erzurum, Serpil, Panettieri, Reynold A., Naga Prasad, Sathyamangla V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449172/
https://www.ncbi.nlm.nih.gov/pubmed/26023787
http://dx.doi.org/10.1371/journal.pone.0125803

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449172/
https://www.ncbi.nlm.nih.gov/pubmed/26023787
http://dx.doi.org/10.1371/journal.pone.0125803

Ejemplares similares