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Defective Resensitization in Human Airway Smooth Muscle Cells Evokes β-Adrenergic Receptor Dysfunction in Severe Asthma

β(2)-adrenergic receptor (β(2)AR) agonists (β(2)-agonist) are the most commonly used therapy for acute relief in asthma, but chronic use of these bronchodilators paradoxically exacerbates airway hyper-responsiveness. Activation of βARs by β-agonist leads to desensitization (inactivation) by phosphor...

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Detalles Bibliográficos
Autores principales:	Gupta, Manveen K., Asosingh, Kewal, Aronica, Mark, Comhair, Suzy, Cao, Gaoyuan, Erzurum, Serpil, Panettieri, Reynold A., Naga Prasad, Sathyamangla V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449172/ https://www.ncbi.nlm.nih.gov/pubmed/26023787 http://dx.doi.org/10.1371/journal.pone.0125803

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